Study of the ultrastructural and functional expression of the hepatocyte genome under conditions of prolonged depression of protein biosynthesis by cycloheximide. III
Galkin, A.P.; Andrianov, V.M.; Mitrokhin, I.I.; Todorov, I.N.
Tsitologiia i Genetika 9(4): 291-294
1975
ISSN/ISBN: 0564-3783 PMID: 1209736 Document Number: 87743
Dynamics of changes in mtRNA synthesis and mitochondria ultrastructure is strictly dependent on the level of inhibition of biosynthesis of cytoplasm proteins and "soluble" proteins of mitochondria by cycloheximide in hepatocytes: 1-6 hrs later a progressive weakening of protein synthesis is accompanied by a drop in mtRNA synthesis and essential destruction of mitochondria; from 12 to 24 hrs a partial restoration of protein biosynthesis induces the processes of the above-mentioned indexes normalization.