The effect of translation inhibitor cycloheximide on expression of mammalian genes
Chesnokov, V.N.; Mertvetsov, N.P.
Biokhimiia 55(7): 1276-1278
1990
ISSN/ISBN: 0320-9725 PMID: 2223902 Document Number: 356853
The data concerning the cycloheximide influence on individual mRNA content, transcription rate and chromatin structure in mammalian cells are reviewed. The putative mechanism of cycloheximide effect is explained as being due to the existence of short-living regulatory proteins. It is concluded that cycloheximide is a helpful tool in the study of regulation of gene expression in mammalian cells.
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