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Antiheparin properties of synthetic polycations

Dubovik, V.V.; Etlis, V.S.; Baluda, V.P.; Sushkevich, G.N.; Shevchuk, A.S.

Farmakologiia i Toksikologiia 38(2): 193-198

1975

ISSN/ISBN: 0014-8318
PMID: 1227887
Document Number: 87390
The toxicity of differently structured polymeric compounds for mice (intravenously) and their antiheparin properties in in vitro and in vivo tests were studied. The antiheparin activity display polymers containing amino groups or onium atoms of nitrogen, sulphur and phosphorus in various structures. The antagonism to heparin is due to the polymers being endowed with polycationic properties.

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