Cutaneous Infections: a Simplified Technic for Selecting Antibiotic Therapy
Goldberg, H.C.; Hanfling, S.L.
Journal of the Medical Society of New Jersey 61: 57-61
1964
ISSN/ISBN: 0025-7524 PMID: 14123906 Document Number: 8643
1. In 261 patients with skin infections (approximately half of which were secondary to various dermatic lesions or underlying skin disease), the sole treatment used was the topical application of amphomycin 0.5 per cent neomycin 0.5 per cent and hydrocortisone 1 per cent in an oil-in-water emulsiont2. Satisfactory results were obtained by 165 (83 per cent) of 200 patients. In the remaining 61 patients, all with pustular acne, satisfactory responses occurred in only 29 (47 per cent). No sensitivity reactions were observed. However, two patients, both of whom had hypostatic leg infections, comp'ained of dermal irritation. 3. In vitro sensitivity testing of the predominant infecting organism isolated from 50 of the 261 patients, indicated greater sensitivity to amphomycin than to bacitracin, penicillin or polymyxin. 4. Clinical response correlated with the sensitivity findings in 81 per cent of the patients tested, excluding those with pustular acne. 5. Amphomycin - neomycin - hydrocortisone (Amphocortrin®) in an oil-in-watcr emulsion baset is an effective topical antimicrobial medication for the treatment of a wide variety of primary and secondary skin infections.
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