Eosinophilic granuloma (histiocytosis-X) with lung and bone manifestations
Schneider, K.; Erd, W.; Lobenwein, E.; Penner, E.; Willvonseder, R.
Wiener Klinische Wochenschrift 87(15): 486-488
1975
ISSN/ISBN: 0043-5325 PMID: 1226755 Document Number: 85378
A 26 year-old male presented with a spontaneous pathological fracture of the right femur caused by an osteolytic lesion. A chest X-ray demonstrated the coexistence of interstitial pulmonary fibrosis. Fibrocaseous tuberculosis and widespread malignancy were ruled out by appropriate investigations. The differential diagnosis, as based on the histological examination of the bone tumour, rested between hyperparathyroidism complicated by pulmonary disease and eosinophilic granuloma with lung manifestations. Hyperparathyroidism was ruled out by the absence of clinical and biochemical evidence of a disturbance of calcium metabolism. The diagnosis of histiocytosis-X was established by the histological appearance of the lung biopsy.