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1- (2-Diethylaminoethyl) -3,4-pentamethylenepyrazole and N2-substituted bornylenepyrazoles

Schenone, P.; Longobardi, M.; Bondavalli, F.

Il Farmaco; Edizione Scientifica 30(6): 456-463

1975

ISSN/ISBN: 0430-0920
PMID: 1140382
Document Number: 85371
An unambiguous synthesis of 1-(2-diethylaminoethyl)-3,4-pentamethylenepyrazole (III) by acid cyclization of 2-(2-cycloheptanonyl)-1,3-dioxolane 2-diethylaminoethylhydrazone, and of N2-methyl and N2-(2-diethylaminoethyl)bornylenepyrazole (VIII) and (IX), by heating the hydrazones from 3-hydroxymethylene-2-bornanone and methylhydrazine or 2-diethylaminoethylhydrazine respectively, is described. (III) showed antiinflammatory activity and (VIII) an anticonvulsant action.

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