Cytoenzymochemical effects of some antiblastic drugs and prediction of response to chemotherapy in acute leukemias
Micu, D.; Gociu, M.; Zamfirescu-gheorghiu, M.; Mihăilescu, E.; Cheţa, D.; Cheţa, N.; Astaldi, A.
Medecine Interne 13(3): 199-203
1975
ISSN/ISBN: 0377-1202 PMID: 1059233 Document Number: 85228
Over 20 cytoenzymochemical tests were carried out in 152 patients with different types of acute leukemia to estimate the effects of some antiblastic drugs such as L-asparaginase, Purinethol, Methotrexate, Endoxan, Vinchristine, Cytosine Arabinoside a.o. The patients selected for the study were carefully examined before treatment at different moments during and/or at the end of the treatment. The effects of these drugs on the blast cells were mild when the cellular populations had a low rate of nucleic acid synthesis, high glycogenic score and high amounts of lipids or an important oxidative enzymatic activity. The enzymatic prediction tests: the acid phosphate deviation test and the succinic dehydrogenase inhibition test including the variant suggested by some of the authors - the latic dehydrogenase inhibition test - gave satisfactory results only in certain cases of acute leukemia.