Predictive tests for the response to cancer chemotherapy: limitations related to the prediction of rare events
Rozencweig, M.; Staquet, M.
Cancer Treatment Reports 68(4): 611-613
1984
ISSN/ISBN: 0361-5960 PMID: 6713417 Document Number: 224370
The reliability of a predictive test may be characterized by its sensitivity and specificity. The probability that a predicted event will actually occur depends on these indexes as well as the frequency of the predicted event. If such a test is used to predict for the therapeutic effect of single-agent chemotherapy in cancer patients, its predictive value is markedly affected by a generally low therapeutic efficacy in an unselected population.
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