Integration and expression of the oncornavirus type D genome in transplantable cells
Zhdanov, V.M.; Mazurenko, N.N.; Bukrinskaia, A.G.; Volkova, M.I.; Kosiakova, N.P.
Voprosy Onkologii 21(8): 64-68
1975
ISSN/ISBN: 0507-3758 PMID: 1166653 Document Number: 84316
The authors investigated five cell cultures producing oncornaviruses type D by the method of molecular hybridization of viral nucleic acids with cell nucleic acids. It was shown that nuclear DNA of the cell lines under study contained scores and hundreds of viral RNA genome-equivalents, while cytoplasmatic RNA contained hundreds and thousands of viral genomes. Viruses produced by the cultures involved are found to be identical or highly similar to nucleotid sequences of their nucleic acids.