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The role of neuromediators in changes in the character of respiration and in its correction following cranio-cerebral trauma

Bazarevich, G.Ia.; Kirillov, A.L.

Zhurnal Nevropatologii i Psikhiatrii Imeni S.S. Korsakova 75(11): 1656-1659

1975

ISSN/ISBN: 0044-4588
PMID: 1210945
Document Number: 83835
Experimental studies on dogs and clinical examinations of patients with brain injuries permitted to state that the activity of the sympathicoadrenal system in the posttraumatic period is increased. The cholinergic processes in such conditions are inhibited, the concentration of blood serotonin is decreased. Depending upon the character of changed neurohumoral blood factors the parameters of external respiration (hypotachypnoe with respiratory acidosis) are also changed. In such condition hydrocortison fulfills the normalizing effect on the respiratory function only in a stimulation of the inhibited cholinergic system by cholinomimetics.

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