Alkaline phosphatases in patients in chronic hemodialysis
Wauters, J.P.; Balant, L.; Leski, M.; Fabre, J.; Rosenbusch, C.A.
Schweizerische Medizinische Wochenschrift 105(51): 1774-1776
1975
ISSN/ISBN: 0036-7672 PMID: 1215974 Document Number: 83673
The alkaline phosphatases (AP) have been studied in 28 patients on chronic hemodialysis. Total AP averaged 49 IU/1 while 4 out of the 28 patients exhibited pathologic values (above 60 IU/1). Determination of iso-AP by acrylamide gel electrophoresis revealed the existence of an intestinal band in 50% of cases, thought this is not observable in a control population. The only relationship seen between the presence of the intestinal iso-AP and different parameters concerned the blood groups O and B. Significant increase of total AP is in all cases due to a bone iso-AP. During a hemodialysis session a mean increase of 30% in total AP has been noted. An increase in total AP is observed in only 2 cases out of 17.