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Acute effects of hemodialysis on circulating parathormone, osteocalcin and alkaline phosphatase in patients with chronic renal failure

Broulík, P.; Hrubý, M.

Casopis Lekaru Ceskych 132(22): 681-683

1993

ISSN/ISBN: 0008-7335
PMID: 8293434
Document Number: 410817
The authors investigated biochemical indicators of the phosphocalcium metabolism in 18 patients dialyzed for prolonged periods on account of chronic renal failure before and after 5-hour dialysis. During dialysis serum creatinine and phosphorus levels declined and serum calcium levels rose. The level of immunoreactive parathyroid hormone (C-terminal), total alkaline phosphatase and gamma-glutamyl transferase did not change. During five hours of dialysis, as compared with alkaline phosphatase, mainly its bone isoenzyme, a marked increase of osteocalcin, an index of de novo bone formation, was recorded. From the investigation it is obvious that osteocalcin with a half-life of 5 minutes is an index of acute changes of the bone metabolism and its rise during dialysis indicates the favourable effect of dialysis on osteoblast activity.

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