Trichlortriethylamine (TS-160 Spofa) in combination chemotherapy of malignant lymphomas
Klener, P.; Donner, L.
Neoplasma 22(1): 55-62
1975
ISSN/ISBN: 0028-2685 PMID: 1097949 Document Number: 83280
Thirteen patients with disseminated malignant lymphomas were treated with combination chemotherapy which included trichlortriethyl amine (TS-160), vincristine (Oncovin), procarbazine hydrochloride (Natulan) and prednisone. All patients but two received some form of chemotherapy and/or radiotherapy prior to being started on four-drug regimen. Good response to the combination chemotherapy was recorded in 84% of patients, while complete remission was achieved in 23% of cases. Drug toxicity has not proved to be a major problem in the combination used. Nausea and vomiting were the side effects the most frequently observed.