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Interaction of heart glycosides and phenobarbital

Káldor, A.; Somogyi, G.; Debreczeni, L.A.; Gachályi, B.

International Journal of Clinical Pharmacology and Biopharmacy 12(4): 403-407

1975

ISSN/ISBN: 0340-0026
PMID: 1205654
Document Number: 82921
One week's administration of phenobarbital does not affect the disappearance of a single dose of digitalis glycosides from the serum of man. The increase of bile flow and of liver weight produced by phenobarbital in the rat is not further enhanced by glycosides. In case of acute digitalization, the enzyme inducing effect of barbiturates has probably no clinical significance.

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