Effect on nitrous oxide on the anaesthetic requirement of enflurane
Torri, G.; Damia, G.; Fabiani, M.L.
British Journal of Anaesthesia 46(7): 468-472
1974
ISSN/ISBN: 0007-0912 PMID: 4458769 Document Number: 80665
The effect of nitrous oxide on the minimum alveolar concentration of enflurane required to prevent movement in response to skin incision in 50% of subjects (MAC) has been investigated in two groups of 16 patients. The end-tidal enflurane concentration was held constant for 25-36 min in order to equilibrate the brain with the alveolar anasthetic partial pressure. When nitrous oxide (30%) was present in the inspired mixture the MAC of enflurane was 1.17%; the value decreased to 0.57% when 70% nitrous oxide was used.