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The role of iron in nonspecific resistance to infection induced by endotoxin

Elin, R.J.; Wolff, S.M.

Journal of Immunology 112(2): 737-745

1974

ISSN/ISBN: 0022-1767
PMID: 4591977
Document Number: 79851
In vitro studies showed a positive correlation between the growth of Candida albicans in serum from mice obtained at daily intervals for 10 days after endotoxin or saline injection and the percentage Fe saturation of the serum. In vivo studies, in which 1 of 4 different concs. of Fe as ferric ammonium citrate was injected into control and endotoxin-treated mice at the time of challenge with C. albicans, showed that the rate of mortality of mice was directly related to the conc. of Fe injected. The endotoxin-induced nonspecific resistance was negated and reversed by Fe administration.

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