Simulated microgravity-induced vascular hyporesponsiveness: role of signal transduction
Kahwaji, C.I.; Sangha, D.S.; Sheibani, S.; Ashori, M.; Nguyen, H.; Kim, Y.; Purdy, R.E.; Purdy, R.E.
Proceedings of the Western Pharmacology Society 42: 9-12
1999
ISSN/ISBN: 0083-8969 PMID: 10697673 Document Number: 7633
In conclusion, the present results demonstrate that HU treatment caused hyporesponsiveness to NE, but not to serotonin. The evidence suggests the hyporesponsiveness to NE could be due to HU-mediated uncoupling of the al adrenoceptor in the aorta from some, but not all, of the second messenger pathways studied.
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