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Simulated microgravity impairs vascular contractility: role of nitric oxide-dependent vasodilator mechanisms

Sangha, D.S.; Vaziri, N.D.; Ding, Y.; Han, S.; Alem, N.; Chen, Y.A.; Purdy, R.E.; Purdy, R.E.

Proceedings of the Western Pharmacology Society 42: 5-7

1999

ISSN/ISBN: 0083-8969
PMID: 10697672
Document Number: 7632
The observed in vivo hyporesponsiveness to NE suggests that the vascular effect of HU treatment is sufficiently generalized to influence total peripheral resistance and, therefore, blood pressure. The larger effect of aminoguanidine on blood pressure in HU compared to control rats indicates that increased iNOS activity made a larger contribution to the resting blood pressure in the HU rats. Since this contribution is in the direction of vasodilatation and blood pressure lowering, blockade of iNOS results in a greater blood pressure elevation in HU rats. The in vivo data strongly suggest that vascular iNOS expression and/or activity is greater in the HU rats.

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Simulated microgravity impairs vascular contractility: role of nitric oxide-dependent vasodilator mechanisms

Kahwaji, C.I.; Sangha, D.S.; Sheibani, S.; Ashori, M.; Nguyen, H.; Kim, Y.; Purdy, R.E.; Purdy, R.E. 1999: Simulated microgravity-induced vascular hyporesponsiveness: role of signal transduction Proceedings of the Western Pharmacology Society 42: 9-12
Sonin, D.L.; Galagudza, M.M.; Syrenskiĭ, A.V.; Egorova, E.I.; Nekrasova, M.K.; Tsyrlin, V.A. 2011: Contribution of nitric oxide in the mechanisms of flow-dependent vasodilation in normo- and hypertensive rats Rossiiskii Fiziologicheskii Zhurnal Imeni I.M. Sechenova 97(8): 814-823
Taguchi, H.; Heistad, D.D.; Chu, Y.; Rios, C.D.; Ooboshi, H.; Faraci, F.M. 1996: Vascular expression of inducible nitric oxide synthase is associated with activation of Ca(++)-dependent K+ channels Journal of Pharmacology and Experimental Therapeutics 279(3): 1514-1519
Mayer, M. 1994: Nitric oxide and mechanisms of vascular and tissue damage. new hope for research and therapy of multiple sclerosis Der Nervenarzt 65(12): 819-827
Shvalev, V.N. 2007: Age related changes of regulatory mechanisms of cardio-vascular system and significance of nitric oxide synthase in the norm and pathology Kardiologiia 47(5): 67-72
Visontai, Z.Z.; Rigó, J.; Dézsi, L. 1995: The role of vascular nitric oxide (NO) in the pathomechanism of pre-eclampsia Orvosi Hetilap 136(47): 2547-2551
Naito, Y.; Yoshikawa, T. 2005: Role of nitric oxide derived from inducible nitric oxide synthase in H. pylori-infected gastric mucosal injury Nihon Rinsho. Japanese Journal of Clinical Medicine 63(Suppl 11): 109-115
Sánchez Mendoza, A.; Vázquez Cruz, B.; Escalante Acosta, B.A. 1996: Role of nitric oxide in the modulation of the vascular response to angiotensin Ii in hypertensive rats Archivos del Instituto de Cardiologia de Mexico 66(4): 306-312
D'iakonova, T.L.; Reutov, V.P. 1994: Nitrites block the Ca-dependent habituation of neurons at the level of an electroexcitable membrane: a possible role for nitric oxide Voprosy Meditsinskoi Khimii 40(6): 20-25
Arnal, J.F.; Battle, T.; Ménard, J.; Michel, J.B. 1993: Vasodilator effect of nitric oxide is a necessary counter-regulation in the spontaneously hypertensive rat Archives des Maladies du Coeur et des Vaisseaux 86(8): 1193-1196
Inamori, M.; Shimamura, T.; Nagase, H.; Abe, Y.; Umezawa, T.; Nakajima, A.; Saito, T.; Ueno, N.; Tanaka, K.; Sekihara, H.; Togawa, J-ichi.; Kaifu, H.; Tsuboi, H.; Kayama, H.; Tominaga, S. 2006: mRNA expression of inducible nitric oxide synthase, endothelial nitric oxide synthase and vascular endothelial growth factor in esophageal mucosa biopsy specimens from patients with reflux esophagitis Hepato-Gastroenterology 53(69): 361-365
Yang, Z.; Liu, P. 2001: Role of vascular endothelial growth factor in the genesis of pregnancy induced hypertension and its relationship with nitric oxide Zhonghua Fu Chan Ke Za Zhi 36(3): 143-145
Deng, X.; Wu, J.; Guo, X.; Han, X.; Ding, X. 2000: Effect of 8-bromo-cyclic AMP on neuron specific enolase, heat shock protein, nitric oxide, nitric oxide synthase and nitric oxide synthase mRNA in human retinoblastoma HXO-Rb44 cells and cell differentiation Chinese Medical Journal 113(3): 198-200
Kahwaji, C.I.; Sheibani, S.; Han, S.; Siu, W.O.; Kaka, A.H.; Fathy, T.M.; el-Abbadi, N.H.; Purdy, R.E.; Purdy, R.E. 2000: Evidence that simulated microgravity may alter the vascular nonreceptor tyrosine kinase second messenger pathway Proceedings of the Western Pharmacology Society 43: 75-77
Tan, D.Y.; Zhang, L.Z.; Zhao, Y.T.; Zhao, D.; Tang, J. 1994: Involvement of nitric oxide in the vasodilator and depressor effect of calcitonin gene-related peptide Chinese Medical Journal 107(10): 745-749
Fulton, D.; Quilley, J. 1998: Evidence against anandamide as the hyperpolarizing factor mediating the nitric oxide-independent coronary vasodilator effect of bradykinin in the rat Journal of Pharmacology and Experimental Therapeutics 286(3): 1146-1151
Ohnishi, M.; Oka, M.; Muramatsu, M.; Sato, K.; Kira, S.; Fukuchi, Y. 1999: E4021, a selective phosphodiesterase 5 inhibitor, potentiates the vasodilator effect of inhaled nitric oxide in isolated perfused rat lungs Journal of Cardiovascular Pharmacology 33(4): 619-624
Atsumi, N.; Gomi, S.; Kanemoto, S.; Mihara, W.; Shigeta, O.; Terada, Y.; Jikuya, T.; Sakakibara, Y.; Mitsui, T.; Ninomiya, H. 1996: Management of postoperative pulmonary hypertensive crisis in children--indication and usefulness of inhaled nitric oxide therapy as a pulmonary vasodilator Nihon Kyobu Geka Gakkai 44(12): 2123-2129
Casais, M.; Delgado, S.M.; Vallcaneras, S.; Sosa, Z.; Rastrilla, A.M.ía. 2007: Nitric oxide in prepubertal rat ovary contribution of the ganglionic nitric oxide synthase system via superior ovarian nerve Neuro Endocrinology Letters 28(1): 39-44
Baksu, B.; Davas, I.; Baksu, A.; Akyol, A.; Gulbaba, G. 2005: Plasma nitric oxide, endothelin-1 and urinary nitric oxide and cyclic guanosine monophosphate levels in hypertensive pregnant women International Journal of Gynaecology and Obstetrics: the Official Organ of the International Federation of Gynaecology and Obstetrics 90(2): 112-117