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The role of vascular nitric oxide (NO) in the pathomechanism of pre-eclampsia

Visontai, Z.Z.; Rigó, J.; Dézsi, L.

Orvosi Hetilap 136(47): 2547-2551

1995

ISSN/ISBN: 0030-6002
PMID: 8532319
Document Number: 447251
The significance of nitric-oxide as a biological mediator is increasingly elucidated in various physiological processes. In addition to the endothelium dependent vasodilator effect it also plays an important role as a neurotransmitter. Possible synthesis of endothelial nitric-oxide is an essential factor in the regulation of blood pressure and utero-placental circulation. Recently the relationship of nitric-oxide and preeclampsia has extensively been studied. The results of human studies and animal experiments suggest that insufficient production of endothelial nitric-oxide probably has an important role in the pathomechanism of preeclampsia.

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