Stability of vinca alkaloid anticancer drugs in three commonly used infusion fluids

Beijnen, J.H.; Vendrig, D.E.; Underberg, W.J.

Journal of Parenteral Science and Technology a Publication of the Parenteral Drug Association 43(2): 84-87

1989


ISSN/ISBN: 0279-7976
PMID: 2709240
Document Number: 756
The chemical stabilities of the vinca alkaloid anticancer drugs vinblastine, vincristine, and vindesine have been studied in three commonly used infusion fluids at 4 and 25 degrees C. The infusion fluids were: 0.9% sodium chloride, 5% dextrose, and Ringer's Lactate injection. Stability has been measured by using a stability-indicating high performance liquid chromatographic assay with ultraviolet detection. At 4 degrees C no significant degradation of the vinca alkaloids occurred within a storage period of three weeks. The stability tests at 25 degrees C also revealed that vinblastine, vincristine, and vindesine are stable (greater than 95% remained) when stored for three weeks at this temperature in 5% dextrose, 0.9% sodium chloride, or Ringer's Lactate infusion fluids.

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Stability of vinca alkaloid anticancer drugs in three commonly used infusion fluids