Pharmacokinetic studies of cyclosporin in Thai kidney transplantation patients
Kungsamrith, T.; Eiam-Ong, S.; Avihingsanon, Y.; Tungsanga, K.; Chusil, S.; Ayudhya, D.P.
Journal of the Medical Association of Thailand 83(11): 1307-1317
2000
ISSN/ISBN: 0125-2208 PMID: 11215860 Document Number: 7325
Pharmacokinetic studies were performed in 10 Thai patients with kidney transplantation who received microemulsion formulation (Neoral) of cyclosporin A (CsA) twice daily. No agents having pharmacokinetic effect on CsA had been used in these patients. The mean values of 12-h AUC (area under the concentration-blood curve) were 4603.63 +/- 344.61 ng x h/ml. CsA concentrations at 2 hours after dosing had the best value of correlation coefficient with the 12-h AUC. Abbreviated AUC could be calculated by stepwise multiple linear regression analysis and linear trapezoidal rule. The latter is more simple and superior to the former one.
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