A case of subclinical IgA nephropathy and cyclosporin associated arteriolopathy diagnosed by non-episode biopsy of graft kidney after renal transplantation
Namba, Y.; Kyakuno, M.; Nakamura, T.; Yamashiro, H.; Okada, M.; Toki, K.; Ichimaru, N.; Kokado, Y.; Takahara, S.; Okuyama, A.; Oka, K.; Imai, E.; Kyo, M.
Hinyokika Kiyo. Acta Urologica Japonica 45(5): 349-353
1999
ISSN/ISBN: 0018-1994 PMID: 10410319 Document Number: 511875
We report a case of subclinical immunoglobulin A (IgA) nephropathy and cyclosporin associated arteriolopathy following renal transplantation. A 39-year-old male with chronic glomerulonephritis received kidney transplantation from a two- human leukocyte antigen (HLA) mismatched cadaveric donor. The initial immunosuppressive therapy was triple-drug therapy with cyclosporin, prednisolone and mizoribine. Four months after transplantation, he had an acute rejection episode, and the renal function was recovered by steroid pulse and 15-deoxyspergualin therapy. Eight years after transplantation, we conducted a non-episode biopsy of the renal allograft to examine subclinical lesions. The histopathological findings showed cyclosporin associatde arteriolopathy (CAA) and IgA nephropathy. There was no sign of acute or chronic rejection. At the present time, the renal function of the allograft is good. In conclusion, the non-episode biopsy of renal allograft is useful for examination of subclinicallesions.