Pharmacokinetics of iopamidol in adults with renal failure
Corradi, A.; Menta, R.; Cambi, V.; Maccarini, P.; Cerutti, R.
Arzneimittel-Forschung 40(7): 830-832
1990
ISSN/ISBN: 0004-4172 PMID: 2222559 Document Number: 716
The pharmacokinetics of iopamidol 370 (Iopamiro), a non-ionic water soluble organic iodine compound, were studied in adults with different degrees of chronic renal failure and in healthy volunteers. After 50 ml were administered i.v., plasma and urine levels were determined. The main pharmacokinetic parameters were calculated on the basis of bi-compartmental open model. There were significant differences from healthy volunteers in t1/2.beta., which increased with the degree of renal failure as the clearance values decreased. t1/2.beta. was equal to 1.67 h in healthy volunteers, 4.24 h in patients with mild renal failure and 10.03 h in patients with severe renal failure. The clearance decreased as follows: 0.11 (1/h kg) in healthy volunteers, 0.06 (l/h kg) in patients with mild renal failure and 0.02 (l/h kg) in patients with severe renal failure. No significant differences were found in distribution volume values nor in t1/2.alpha.
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