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Pharmacokinetics of amoxycillin and ampicillin in patients with renal failure

Ksiazek, A.; Twardowski, Z.; Przyborowski, L.; Majdan, M.; Sokołowska, G.; Hopkała, H.; Solski, J.; Zbikowska, A.; Misztal, G.; Bocheńska-Nowacka, E.

Annales Universitatis Mariae Curie-Sklodowska. Sectio D Medicina 38: 79-86

1983

ISSN/ISBN: 0066-2240
PMID: 6600085
Document Number: 214870
Disturbance of renal function is connected with the change of pharmacokinetics of used drugs. In many studies a significant impairment of distribution, biotransformation, binding of drugs to plasma protein and accumulation of toxic metabolites has been observed (7). Renal failure can increase sensitivity to administered drugs and on the other hand, administered drugs can aggravate renal disease and intensification of renal failure. With regard to a very complicated mechanism of reciprocal activity between renal failure and applied drugs, it seems possible that mathematical formulas for the calculation of administered doses should be applied only exceptionally in renal failure (7). This examination should be specially made with drugs that have urinary excretion as a major pathway of elimination. Semisynthetic penicillines such as amoxycillin and ampicillin produced by Tarchomin "Polfa" belong to these drugs.

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Hardin, T.C.; Butler, S.C.; Ross, S.; Wakeford, J.H.; Jorgensen, J.H. 1994: Comparison of ampicillin-sulbactam and ticarcillin-clavulanic acid in patients with chronic renal failure: effects of differential pharmacokinetics on serum bactericidal activity PharmacoTherapy 14(2): 147-152
Maher, J.F. 1984: Pharmacokinetics in patients with renal failure Clinical Nephrology 21(1): 39-46
Li, P.; Cai, Q.; Gao, S.; Liu, G.L.; Cui, R.L.; Yang, X.Y. 1995: Pharmacokinetics of ceftizoxime in renal failure patients without dialysis Zhongguo Yao Li Xue Bao 16(5): 402-404
Rondelli, I.; Acerbi, D.; Ventura, P. 1991: Steady-state pharmacokinetics of ipriflavone and its metabolites in patients with renal failure International Journal of Clinical Pharmacology Research 11(4): 183-192
Rovei, V.; Leroy, A.; Sauvanet, J.P.; Braithwaite, R.; Coquelin, J.P.; Gomeni, R.; Morselli, P.L.; Fillastre, J.P. 1981: Comparative pharmacokinetics of antrafenine in healthy volunteers and in patients with chronic renal failure Therapie 36(1): 21-26
Tomino, Y.; Fukui, M.; Hamada, C.; Inoue, S.; Osada, S. 1998: Pharmacokinetics of cefdinir and its transfer to dialysate in patients with chronic renal failure undergoing continuous ambulatory peritoneal dialysis Arzneimittel-Forschung 48(8): 862-867
Degen, J.; Wölke, E.; Seiberling, M.; Pintar, P.; Höxter, G.; Steinhauer, H.B.; Fischer, W. 1993: Comparative study of the pharmacokinetics of amitriptyline oxide and trimipramine after single administration in healthy male probands and patients with renal failure Medizinische Klinik 88(3): 129-133; 171
Sieniawska, M.; Wróblewska-Kałuzewska, M.U.; Korniszewska, J.; Wierzba, K. 1980: Ampicillin dosage for children depending on the degree of renal failure and body weight. IV Pediatria Polska 55(6): 691-698
Warnke, J.P.; Wildfeuer, A.; Eibel, G.; Pfaff, G.; Klammer, A. 1998: Pharmacokinetics of ampicillin/sulbactam in patients undergoing spinal microneurosurgical procedures International Journal of Clinical Pharmacology and Therapeutics 36(5): 253-257
Corradi, A.; Menta, R.; Cambi, V.; Maccarini, P.; Cerutti, R. 1990: Pharmacokinetics of iopamidol in adults with renal failure Arzneimittel-Forschung 40(7): 830-832
Koeppe, P.; Höffler, D.; Strobel, K. 1987: Pharmacokinetics and dose recommendations of carumonam in renal failure Arzneimittel-Forschung 37(1): 65-69
Guardiola, J.M.; Mangues, M.A.; Domingo, P.; Martínez, E.; Barrio, J.L. 1998: Indinavir pharmacokinetics in haemodialysis-dependent end-stage renal failure Aids 12(11): 1395
Bouletreau, P.; Meunier, J.; Kérihuel, J.C.; Ritter, W. 1985: Clinical study of muzolimine in acute renal failure, pharmacodynamics and pharmacokinetics Zeitschrift für Kardiologie 74(Suppl 2): 96-99
Lin, J.H.; Levy, G. 1982: Effect of experimental renal failure on sulfate retention and acetaminophen pharmacokinetics in rats Journal of Pharmacology and Experimental Therapeutics 221(1): 80-84
Kalabukhova, N.F. 1973: Ampicillin pharmacokinetics Antibiotiki 18(5): 416-420
Moe, G.W.; Forster, C.; de Bold, A.J.; Armstrong, P.W. 1990: Pharmacokinetics, hemodynamic, renal, and neurohormonal effects of atrial natriuretic factor in experimental heart failure Clinical and Investigative Medicine 13(3): 111-118
Mehta, A.P.; Phutane, L.; Patel, M.H.; Rupwate, R.U.; Kamat, S.R. 1991: Comparative study of amoxycillin and amoxycillin/clavulanic acid in lower respiratory infections Journal of the Association of Physicians of India 39(3): 251-253
Modr, Z.; Dvorácek, K.; Krebs, V.; Janků, I. 1975: Pharmacokinetics of amoxicillin, pivampicillin and ampicillin Casopis Lekaru Ceskych 114(20): 611-615
Okada, K.; Kuno, T.; Yanai, M.; Maeda, H.; Takahashi, S.; Hatano, M. 1988: The effects of CaCO3 on renal osteodystrophy--comparison of patients with chronic renal failure in the predialytic stage and patients undergoing maintenance hemodialysis Nihon Jinzo Gakkai Shi 30(8): 1053-1062
Bennett, W.M.; Craven, R. 1976: Urinary tract infections in patients with severe renal disease. Treatment with ampicillin and trimethoprim-sulfamethoxazole JAMA 236(8): 946-948