Cardiac amyloidosis secondary to multiple myeloma
Parrilla, F.; Calderon, R.E.; Figueroa, R.; Gurrea, C.
Boletin de la Asociacion Medica de Puerto Rico 105(2): 39-42
2013
ISSN/ISBN: 0004-4849 PMID: 23882988 Document Number: 702342
Amyloidosis is a multisystemic disease caused by extracellular deposition of pathologic beta fibrillar proteins in multiple organs. Deposited fibrils can be either innunoglobulin light chanis or amyloid-A protein. The incidence of anyloidosis derived from anyloid-A protein, usually associated to an underlying disease, has been dimisishing over the decades in the United States producing clinical evidence of cardiac involvement in less than 5% of all cases. The extent of cardiac involvement is the determining prognostic factor. Early diagnosis and therapy aimed at the underlying disease may halt progression of cardiac dysfuction and improve prognosis. We report a case of a 63-year-old man who was diagnosed with cardiac amyloidosis secondary to multiple myeloma.
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