Weekly cyclophosphamide and alternate-day prednisone: an effective secondary therapy in multiple myeloma
Wilson, K.; Shelley, W.; Belch, A.; Brandes, L.; Bergsagel, D.; Klimo, P.; White, D.; Willan, A.
Cancer Treatment Reports 71(10): 981-982
1987
ISSN/ISBN: 0361-5960 PMID: 3652060 Document Number: 4878
Intravenous or oral cyclophosphamide, 150-250 mg/m2 (500 mg maximum), once per week with alternate-day oral prednisone, 100 mg, was given to 57 myeloma patients resistant to melphalan and prednisone (MP). Seven responses in 28 primary MP-resistant patients and ten responses in 29 secondary MP-resistant patients were observed. Previous response to MP was not a significant factor in predicting response to weekly cyclophosphamide and alternate-day prednisone. The results suggest that the regimen of weekly cyclophosphamide and alternate-day prednisone may be as effective as more aggressive regimens in the treatment of patients with myeloma who have failed MP therapy. However, a randomized trial would be required to determine the relative contributions of cyclophosphamide and prednisone to the effectiveness of this regimen.
Document emailed within 1 workday
