Non-canonical Wnt signaling and cellular responses
Nishita, M.; Saji, T.; Minami, Y.
Clinical Calcium 29(3): 291-297
2019
ISSN/ISBN: 0917-5857 PMID: 30814373 Document Number: 699255
Non-canonical Wnt signaling, including planar cell polarity and Ca2+ pathways, plays crucial roles in developmental processes, including morphogenesis and tissue-/organo-genesis, in animals. Ror2 receptor tyrosine kinase mediates non-canonical Wnt signaling by acting as a receptor for Wnt5a, which also inhibits canonical Wnt signaling. Dysregulation of Wnt5a-Ror2 signaling causes a wide range of developmental defects and cancer progression. Recently, Ror2-mediated non-canonical Wnt signaling has also been shown to induce formation of filopodia that facilitates transport of Wnt to neighboring cells, thereby activating canonical Wnt signaling there.