Cellular origins of co-stimulator (IL2) and its activity in cytotoxic T lymphocyte responses
Shaw, J.; Caplan, B.; Paetkau, V.; Pilarski, L.M.; Delovitch, T.L.; McKenzie, I.F.
Journal of Immunology 124(5): 2231-2239
1980
ISSN/ISBN: 0022-1767 PMID: 6965968 Document Number: 160736
Production of co-stimulator (Interleukin 2, IL2), a Con cells to sheep erythrocytes, in this way resembling T cell-replacing factor. It also restores the CTL response of lymph node lymphocytes that were depleted of adherent cells. Thus, co-stimulator is a product of interaction between adherent cells (macrophages) and T helper cells, and it replaces both of these in proliferative or immune responses by T cells. The factor does not bear Ia antigens, and it is not H-2 restricted; this distinguishes it from allogeneic effect factor (AEF).