Aggregated proteins in malignant and benign neoplasms
Zabolotnyi, D.I.; Belousova, A.A.; Zabolotna, D.D.; Savchenko, T.D.; Voroshylova, N.M.; Timchenko, M.D.; Tsvirinko, I.R.; Verevka, S.V.
Experimental Oncology 41(1): 61-68
2019
ISSN/ISBN: 1812-9269 PMID: 30932409 Document Number: 698690
To evaluate the presence of the aggregated proteins in malignant and benign neoplasms for clarifying the role of impaired protein metabolism in the formation of the altered tissues. The histological specimens prepared from the operative materials of 196 patients with different forms of malignant and benign neoplasms were stained with Congo red and Thioflavin T and studied under the light and polarization microscope. The various forms of β-stacked protein aggregates (β-SPA) inclusions were detected in amyloids, keloid tissue, benign polyps, and several malignant tumors. The formation of non-functional protein aggregates proves the complex character of the impairment of protein metabolism resulting in local or systemic accumulation of secondary protein toxins results in β-SPA formation as the self-sustaining complex of parametabolic processes. The β-SPA formation is of considerable interest since their properties lead to the impairment of the normal physiological processes in adjacent tissues ensuring the chronic course of the pathology.