A Case of Chemotherapy-Induced Hyperammonemic Encephalopathy in a Patient with Metastatic Colon Cancer
Tanaka, T.; Miwa, K.; Fukahori, M.; Yomoda, T.; Sakaue, T.; Nagasu, S.; Ushijima, T.; Koga, H.; Torimura, T.
Gan to Kagaku Ryoho. Cancer and ChemoTherapy 46(2): 259-262
2019
ISSN/ISBN: 0385-0684 PMID: 30914529 Document Number: 698287
A 70-year-old man was diagnosed with colon cancer with multiple liver metastases.He was administered modified FOLFOX6 plus panitumumab as first-line chemotherapy.He showed consciousness disturbance on the 3rd day during the 8 cycle and was hospitalized urgently.We diagnosed him with 5-FU-induced hyperammonemia.Administration of branchedchain amino acid preparation improved his consciousness disturbance.After changing the regimen of chemotherapy to another one containing oral fluoropyrimidine, the recurrence of hyperammonemic encephalopathy was not found.
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