Brain-on-a-Chip: a Human 3D Model for Clinical Application
Muzzi, L.; Martinoia, S.; Frega, M.
Studies in Health Technology and Informatics 261: 274-279
2019
ISSN/ISBN: 1879-8365 PMID: 31156129 Document Number: 698286
The main goal of this research is to design, develop and implement an efficient protocol to generate 3D neural cultures derived from human induced Pluripotent Stem Cells (hiPSCs) coupled to Micro Electrode Arrays (MEA) in order to obtain an engineered and controlled brain-on-a-chip model. The use of patient specific iPSCs may offer novel insights into the pathophysiology of a large variety of disorders, including numerous neurodevelopmental and late-onset neurodegenerative conditions. With these in vitro patient specific models, we may have the possibility to test drugs and find ad hoc therapies in the direction of precision medicine.