Mozart's music and multidrug-resistant epilepsy: a potential EEG index of therapeutic effectiveness
Bedetti, C.; D'Alessandro, P.; Piccirilli, M.; Marchiafava, M.; Baglioni, A.; Giuglietti, M.; Frondizi, D.; Menna, M.; Elisei, S.
Psychiatria Danubina 30(Suppl. 7): 567-571
2018
ISSN/ISBN: 0353-5053 PMID: 30439848 Document Number: 697663
Multidrug-resistant epilepsy is a pathological condition that affects approximately one-third of patients with epilepsy, especially those with associated intellectual disabilities. Several non-pharmacological interventions have been proposed to improve quality of life of these patients. In particular, Mozart's sonata for two pianos in D major, K448, has been shown to decrease interictal electroencephalography (EEG) discharges and recurrence of clinical seizures in these patients. In a previous study we observed that in institutionalized subjects with severe/profound intellectual disability and drug-resistant epilepsy, a systematic music listening protocol reduced the frequency of seizures in about 50% of cases. This study aims to assess electroencephalography as a quantitative (qEEG) predictive biomarker of effectiveness of listening to music on the frequency of epileptic discharges and on background rhythm frequency (BRF).