Molecular epidemiology of multidrug-resistant organisms
Mitsuda, T.
Nihon Rinsho. Japanese Journal of Clinical Medicine 70(2): 201-204
2012
ISSN/ISBN: 0047-1852 PMID: 22413518 Document Number: 662764
Recent advance in molecular epidemiology of multidrug-resistant organisms (MDROs) was described. Most of MDROs are spreading over the world in a short period, monitoring of certain epidemic strains of MDROs is very important. Since Cantor et al. developed pulsed-field gel electrophoresis (PFGE) in 1984, genotyping tools became major tools for laboratory based-epidemiologic analysis. Recent advance was developed by two major technologies. One is multilocus sequence typing (MLST) and the other one is matrix assisted laser desorption ionization-time of flight-mass spectrometry (MALDI-TOF-MS). MALDI-TOF-MS technology is still under developing, but near future it will become major tools for MDROs molecular epidemiology.