Advances in the studies of teratospermia-related genes
Ma, S.; Dai, X.-W.; Zheng, L.-W.
Zhonghua Nan Ke Xue 24(10): 937-940
2018
ISSN/ISBN: 1009-3591 PMID: 32212452 Document Number: 697418
Sperm morphology is one of the important indicators for the evaluation of male fertility. In recent years, there has been a gradual increase in the incidence of male infertility and that of infertility-associated teratospermia. Scholars at home and abroad are trying to explore the pathogenesis of teratospermia at the molecular level. With a review of recent studies on teratospermia, we present an overview of abnormal sperm morphology in the aspects of sperm head, neck and tail deformities, focusing on teratospermia-related genes, such as SPATA16, DPY19L2, PICK1, ZPBP1, SIRT1, AURKC, SPATA6, SUN5, ODF1, and DNAH1, aiming to provide a theoretical basis and some reference for the diagnosis and treatment of teratospermia.