Chemosensitivity-related genes of breast cancer detected by DNA microarray
Ikeda, T.; Jinno, H.; Shirane, M.
Anticancer Research 27(4c): 2649-2655
2007
ISSN/ISBN: 0250-7005 PMID: 17695428 Document Number: 611761
Background: The feasibility of a preoperative docetaxel/5'-deoxy-5-fluoroutidine (5-DFUR) regimen for breast cancer patients was examined and the genes related to the response to it was investigated. Patients and Methods: Women with advanced breast cancer were treated with docetaxel (60 mg/m(2), day 1) and 5'-DFUR (800 mg/day, on days 1-14) q3 weeks by 4 cycles. Microarray analysis was carried out using preoperative core biopsy samples. Based on the mRNA expression levels, genes related to clinical and pathological responses were selected. Results: The docetaxel/5'-DFUR regimen showed a 86% clinical response rate including 42% complete response, one pathological complete response and one ductal carcinoma in situ component. In microarray analysis, we identified 6 genes, including IGF-1, and derived a predictive formula with 67% accuracy. In addition, chi(2) analysis revealed a tendency for good response in ER-negative and Her2/neu-positive cases. Conclusion: Microarray analysis enabled us to predict the pathological response to docetaxel/5'-DFUR chemotherapy.