Elevated plasma il-8 concentration is related to severity of systemic inflammation in chronic spontaneous urticaria
Kasperska-Zajac, A.; Grzanka, A.; Damasiewicz-Bodzek, A.; Bieniek, K.; Skrzypulec-Frankel, A.; Stencel-Gabriel, K.; Sikora-Zydek, A.
Journal of Biological Regulators and Homeostatic Agents 31(4): 957-961
2017
ISSN/ISBN: 0393-974X PMID: 29254299 Document Number: 692770
Chronic spontaneous urticaria (CSU) is associated with activation of acute phase response. Questions arise regarding its association with other inflammatory mediators. To determine plasma IL-8 concentration in CSU patients and its association with C-reactive protein (CRP) concentration, a nonspecific inflammatory marker of the disease activity, concentrations of plasma IL-8 and serum CRP were measured in CSU patients and compared with healthy controls. IL-8 and CRP concentrations were significantly higher in CSU patients as compared with the healthy subjects. In addition, there were significant differences in IL-8 and CRP concentrations between CSU patients with moderate-severe symptoms and the healthy subjects. Plasma IL-8 and serum CRP concentrations showed a significant correlation with urticaria activity score (UAS). Additionally, a significant positive correlation was observed between IL-8 and CRP concentrations. Up-regulations of IL-8 and its association with the marker of clinical and inflammatory activity suggest a role of this cytokine in the pathogenesis of CSU.