A new anti-hypoxia sesquiterpene from the rhizome of Petasites japonicas
Xie, Y.-y.; Li, Y.-x.; Sun, Y.-m.; Wang, Y.; Guo, M.-l.
Yao Xue Xue Bao 51(8): 1285-1289
2016
ISSN/ISBN: 0513-4870 PMID: 29906019 Document Number: 691080
A new sesquiterpene, bakkenolide-Ⅵa (1), was isolated from the rhizome of Petasites japonicas (Sieb. et Zucc.) Maxim. The structure was characterized on the basis of various NMR ((1)H, (13)C, (1)H-(1)H COSY, HMQC, HMBC and NOESY) and mass spectrometry data. Bakkenolide-Ⅵa showed potent cerebral hypoxia- ischemia protective activity in mice subjected to decapitation through prolonging the survival time and gasping time. It also exhibited a protective activity against hypoxia injury in PC12 cells in anaerobic culture by inhibition of lactate dehydrogenase (LDH) release.