The Unesterified Fatty Acids in Blood Plasma and Intercellular Medium: Effect of Insulin and Albumin (The Lecture)
Titov, V.N.; Shoibonov, B.B.
Klinicheskaia Laboratornaia Diagnostika 61(2): 93-101
2016
ISSN/ISBN: 0869-2084 PMID: 27455563 Document Number: 690638
The high content of palmitic saturated fatty acid, palmitic triglycerides in food, the large amount of lipoproteins of very low density of the same name in blood, obvious insufficient amount of unesterified fatty acids releasing under lipolysis in blood to meet in vivo requirements in biotransforming energy of ATP are the causes of biological malfunction of homeostasis. As a rule, for every cell in vivo everything is always to be enough. The deficiency of synthesis of ATP by reason of non-optimal substratum for acquirement of ATP by mitochondria is followed by activation also phylogenetically earlier biological function of adaptation, biological reaction of stress. Thus, surplus of palmitic unesterified fatty acid after every food intake forms in vivo biological reaction of "metabolic" stress, deficiency of energy by reason of realization by mitochondria in vivo non-optimal exogenous substratum-palmitic unesterified fatty acid, deficiency of acyl- and acetyl-KoA and prognostically formation of potentially ineffective palmitic alternative of metabolism of fatty acids. The deficiency of palmitic unesterified fatty acids in biological reaction of exotrophy after every intake of food compensates biological reaction of stress, activation of releasing of palmitic unesterified fatty acids from visceral fatty cells of gland as it physiologically occurs in biological reaction of endotrophy. At that, adrenalin increases lipolysis in visceral fatty cells of gland and physiologically late insulin can't inhibit lipolysis in phylogenetically early visceral fatty cells. Increasing of content of unesterifed fatty acids in blood plasma, as it always occurs in vivo, stops absorption of glucose by cells initiating hyperglycemia, hyperinsulinemia, and syndrome of resistance to insulin. The result of such a compensation of biological reaction of exotrophy is biological reaction of endotrophy, condition of "metabolic" stress, depletion of function of β-cells of islets with formation of diabetes mellitus type I, deficiency in vivo of insulin synthesis. The biological role of albumin - transfer of fatty acids in intercellular medium inform of unesterifed fatty acids and prevention of formation of pool of free fatty acids effecting aphysiologically.