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Chemical modification of nucleic acids as a key technology for the development of RNA-based therapeutics

Grünweller, A.; Hartmann, R.K.

Die Pharmazie 71(1): 8-16

2016

ISSN/ISBN: 0031-7144
PMID: 26867347
Document Number: 690153
RNA-based effector molecules (nucleic acid effectors) are important tools in molecular medicine because they offer a strategy to address therapeutically interesting targets that are not "druggable" with classic small molecule inhibitors. However, for in vivo applications, RNA-based effectors require specific chemical modifications to improve their stability and pharmacokinetic properties, as well as to minimize toxic and unspecific off-target effects.

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Levine, A.F.; Fink, L.M.; Weinstein, I.B.; Grunberger, D. 1974: Effect of N-2-acetylaminofluorene modification on the conformation of nucleic acids Cancer Research 34(2): 319-327
Haková, H.; Misúrová, E.; Kropácová, K. 1997: Modification of postradiative changes of nucleic acids by the bacterial extract broncho-vaxom in rat tissues Folia Biologica 43(6): 231-237
Abramova, T.V.; Lebedev, A.V.; Raĭt, A.S. 1988: Diastereomers of nonionic analogs of nucleic acids. V. Alkylation of nucleic acids in the living cells by ethylated derivatives of oligonucleotides containing the residue of nitrous yperite. the effect of the phosphotriester fragment configuration Molekuliarnaia Biologiia 22(5): 1285-1292
Knorre, D.G.; Zarytova, V.F.; Karpova, G.G.; Stephanovich, L.E. 1981: Specific modification of nucleic acids inside the cell with alkylating derivatives of oligonucleotides ethylated at internucleotide phosphates Nucleic Acids Symposium Series 9: 195-198
Kremen, J.; Stríbrná, J.; Sula, J. 1978: Effect of actinomycin D and daunomycin on the biosynthesis of nucleic acids in cells transformed by oncornavirus and on the biosynthesis of viral nucleic acids Sbornik Lekarsky 80(5): 136-141
Tanaka, Y.; Mizokami, M. 2006: Clinical examinations based on nucleic acids of hepatitis viruses Rinsho Byori. Japanese Journal of Clinical Pathology 54(11): 1164-1171
Liu, J.; Luo, G.A.; Wang, Y.M.; Sun, H.W. 2001: Research development of the interaction of small molecules with nucleic acids Yao Xue Xue Bao 36(1): 74-78
Bulychev, N.B.; Vorob'ev, I.N.; Koshkin, A.A.; Shishkin, G.V. 1991: Modification of nucleic acids by reactive oligonucleotide derivatives having a 5'-terminal nitrogen yperite residue, covalently bound with linkers of varying length. Conformation dynamics of group reactivity in complementary complexes Bioorganicheskaia Khimiia 17(6): 795-805
Spiess, E.; Richter, G. 1971: P32-labelling of nucleic acids and the role of phosphate in the nucleic acid metabolism of Euglena greacilis Archiv für Mikrobiologie 78(2): 118-127
Jamin, N.; Dumas, P.; Moncuit, J.; Fridman, W.H.; Teillaud, J.L.; Carr, G.L.; Williams, G.P. 1998: Chemical imaging of nucleic acids, proteins and lipids of a single living cell. Application of synchrotron infrared microspectrometry in cell biology Cellular and Molecular Biology 44(1): 9-13
Shen, Y. 2008: Advances in the development of siRNA-based therapeutics for cancer Idrugs: the Investigational Drugs Journal 11(8): 572-578
Orum, H.; Wengel, J. 2001: Locked nucleic acids: a promising molecular family for gene-function analysis and antisense drug development Current Opinion in Molecular Therapeutics 3(3): 239-243
Iwatsubo, T. 2013: Current status and perspectives on the development of AD therapeutics based on amyloid cascade hypothesis Rinsho Shinkeigaku 53(11): 1039
Tikhonov, O.I. 1978: Development of technology and physico-chemical studies of ointments with a lyophilic phenolic preparation of propolis Farmatsevtychnyi Zhurnal 5: 79-80
Ermacora, M.; Cascone, O.; Wolfenstein-Todel, C.; Biscoglio de Jimenez Bonino, M.; Nowicki, C.; Rivero, J.L.; Santome, J.A. 1988: An approach to the three-dimensional structure of bovine growth hormone based on chemical modification and secondary structure prediction Archivos de Biologia y Medicina Experimentales 21(1): 109-115
Al'tshteĭn, A.D.; Efimov, A.V. 1988: Physico-chemical basis of the genetic code origin: stereochemical analysis of interactions of amino acids and nucleotides based on the progene hypothesis Molekuliarnaia Biologiia 22(5): 1411-1429
Khananshvili, D.; Gromet-Elhanan, Z. 1982: Chemical modification of the beta-subunit isolated from a membrane-bound Fo-F1-ATP synthase: modification by 4-chloro-7-nitrobenzofurazan does not inhibit restoration of ATP synthesis or hydrolysis Biochemical and Biophysical Research Communications 108(2): 881-887
Giles, R.V. 2000: Antisense oligonucleotide technology: from EST to therapeutics Current Opinion in Molecular Therapeutics 2(3): 238-252
Ranasinghe, L. 1983: Recombinant technology in medical research and therapeutics Ceylon Medical Journal 28(2): 57-61
Somin, M.P.; Ostapiuk, S.F. 1989: Development of technology for providing ambulatory health services based on systems principles Sovetskoe Zdravookhranenie 9: 25-29