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Locked nucleic acids: a promising molecular family for gene-function analysis and antisense drug development

Orum, H.; Wengel, J.

Current Opinion in Molecular Therapeutics 3(3): 239-243

2001

ISSN/ISBN: 1464-8431
PMID: 11497347
Document Number: 532624
Locked nucleic acids (LNAs) are a family of conformationally locked oligonucleotide analogs inducing unprecedented binding affinity towards DNA/RNA target sequences. Importantly, by virtue of the structural resemblance of LNAs to natural nucleic acid monomers, a combination of LNA chemistry with other oligonucleotide chemistries can be exploited to fine-tune the properties towards optimized antisense drug development and target validation technology. The first promising antisense results from experiments with LNA in living animals are described.

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Frieden, M.; Orum, H. 2006: The application of locked nucleic acids in the treatment of cancer Idrugs: the Investigational Drugs Journal 9(10): 706-711
Feng, G.; Li, S.; Li, Y.; Bu, H.; Yang, Y.; Lu, Y. 2002: Antisense inhibition of gene expression in human dendritic cells by peptide nucleic acid against CD86 Hua Xi Yi Ke da Xue Xue Bao 33(2): 192-195
Abramova, T.V.; Lebedev, A.V.; Raĭt, A.S. 1988: Diastereomers of nonionic analogs of nucleic acids. V. Alkylation of nucleic acids in the living cells by ethylated derivatives of oligonucleotides containing the residue of nitrous yperite. the effect of the phosphotriester fragment configuration Molekuliarnaia Biologiia 22(5): 1285-1292
Bolívar Zapata, F.G. 1979: In vitro recombination of nucleic acids: molecular genetic engineering Revista Latinoamericana de Microbiologia 21(1): 37-55
Chetverina, H.V.; Samatov, T.R.; Ugarov, V.I.; Chetverin, A.B. 2002: Molecular colony diagnostics: detection and quantitation of viral nucleic acids by in-gel PCR Biotechniques 33(1): 150-2 154 156
Kremen, J.; Stríbrná, J.; Sula, J. 1978: Effect of actinomycin D and daunomycin on the biosynthesis of nucleic acids in cells transformed by oncornavirus and on the biosynthesis of viral nucleic acids Sbornik Lekarsky 80(5): 136-141
Inoue, R.; Ito, Y.; Mori, Y. 2002: The TRP proteins, a rapidly expanding Ca2+ entry channel family and a new molecular target for drug development Nihon Rinsho. Japanese Journal of Clinical Medicine 60(1): 18-24
Wu, Y.; Nishio, H.; Lee, M.J.; Ayaki, H.; Hayashi, A.; Ooba, T.; Ogawa, T.; Sumino, K. 2000: Molecular genetic analysis and mutation screening of the VHL gene in a Japanese family with von Hippel-Lindau disease Kobe Journal of Medical Sciences 46(4): 147-153
Schwartz, J.H.; Swanson, M.E. 1987: Dissection of tissues for characterizing nucleic acids from Aplysia: isolation of the structural gene encoding calmodulin Methods in Enzymology 139: 277-290
Liu, J.; Luo, G.A.; Wang, Y.M.; Sun, H.W. 2001: Research development of the interaction of small molecules with nucleic acids Yao Xue Xue Bao 36(1): 74-78
Kulaev, I.S.; Laibenieks, M.G.; Bobyk, M.A.; Beker, M.E. 1977: Relationship between the content of some fractions of high molecular weight polyphosphates and total nucleic acids upon dehydration of the yeast Saccharomyces cerevisiae Prikladnaia Biokhimiia i Mikrobiologiia 13(6): 893-900
Grünweller, A.; Hartmann, R.K. 2016: Chemical modification of nucleic acids as a key technology for the development of RNA-based therapeutics Die Pharmazie 71(1): 8-16
Maeda, N.; Miyano-Kurosaki, N.; Yamamoto, N. 1998: Drug delivery system (DDS) for the use of antisense oligodeoxynucleotide phosphorothioate in controlling gene expression Nihon Rinsho. Japanese Journal of Clinical Medicine 56(3): 686-690
Sukhorukov, B.I.; Gukovskaia, A.S.; Sukhoruchkina, L.V.; Lavrenova, G.I. 1972: Optical properties and molecular structure of nucleic acids and their components. V. Spectrophotometric determination of thermodynamic parameters for protolytic reactions of cytosine and its N- and O-methyl derivatives Biofizika 17(1): 5-11
Spiess, E.; Richter, G. 1971: P32-labelling of nucleic acids and the role of phosphate in the nucleic acid metabolism of Euglena greacilis Archiv für Mikrobiologie 78(2): 118-127
Rao, K.E.; Shea, R.G.; Yadagiri, B.; Lown, J.W. 1990: Molecular recognition between oligopeptides and nucleic acids: DNA sequence specificity and binding properties of thiazole-lexitropsins incorporating the concepts of base site acceptance and avoidance Anti-Cancer Drug Design 5(1): 3-20
Kumar, B.; Singh, S.; Skvortsova, I.; Kumar, V. 2017: Promising Targets in Anti-cancer Drug Development: Recent Updates Current Medicinal Chemistry 24(42): 4729-4752
Yoshida, A. 2013: Noninvasive analysis of retinal microstructure and function: challenges and a promising future Nippon Ganka Gakkai Zasshi 117(3): 212-244; Discussion 245
Robinson-Benion, C.; Li, Y.X.; Holt, J.T. 1994: Gene transplantation: combined antisense inhibition and gene replacement strategies Leukemia 8(Suppl): S152-S155
Nitta, T. 1994: Gene therapy for brain tumors: antitumor effects of introduction of antisense and tumor suppressor gene (series 2) No Shinkei Geka. Neurological Surgery 22(10): 903-909