The TRP proteins, a rapidly expanding Ca2+ entry channel family and a new molecular target for drug development
Inoue, R.; Ito, Y.; Mori, Y.
Nihon Rinsho. Japanese Journal of Clinical Medicine 60(1): 18-24
2002
ISSN/ISBN: 0047-1852 PMID: 11808331 Document Number: 545736
There is a rapidly expanding protein family which encompasses a broad repertoire of cation-selective channels serving as a continuous Ca2+ entry pathway into the cell. The transient receptor potential protein (TRP) and its relatives, which were originally thought to be Ca (2+)-permeable cation channels activated upon the stimulation of G-protein coupled and tyrosine kinase receptors, are now becoming promising candidates mediating a variety of cellular responses and functions such as mechano/chemo-transduction, oxidative stress, and cell survival/proliferation. This short paper briefly overviews the current knowledge about these proteins as a new target for drug discovery and development.