Successful Treatment of very Early Thrombosis of SAPIEN 3 Valve with Direct Oral Anticoagulant Therapy
Ruparelia, N.; Panoulas, V.F.; Frame, A.; Sutaria, N.; Ariff, B.; Gopalan, D.; Chukwuemeka, A.; Mikhail, G.W.; Malik, I.S.
Journal of Heart Valve Disease 25(2): 211-213
2016
ISSN/ISBN: 0966-8519 PMID: 27989069 Document Number: 689753
Thrombosis of transcatheter aortic valve implantation (TAVI) is an uncommon complication that commonly occurs weeks to months following the procedure. Herein are described the details of a patient who presented with a recurrence of symptoms days after intervention with a bioprosthesis thrombosis that was successfully treated with direct oral anticoagulant (DOAC) therapy and resulted in hemodynamic improvement and resolution of symptoms. Whilst a previous trial of DOAC therapy with mechanical valves was stopped due to elevated events in comparison to warfarin, a TAVI valve may be different, and the rapid onset of action and reduced bleeding risk may be beneficial in this patient group.