PPSB as first choice treatment in the reversal of oral anticoagulant therapy
Strengers, P.F.W.; Drenth, J.C.
Acta Anaesthesiologica Belgica 53(3): 183-186
2002
ISSN/ISBN: 0001-5164 PMID: 12461827 Document Number: 544433
In the treatment of reversal of oral anticoagulant therapy, a number of treatment modalities is available and depends on the severity of the clinical situation and the degree of the coagulopathy. FFP and PPSB (PCC) are commonly used in the treatment and/or in combination with cessation of oral anticoagulant therapy and administration of Vitamin K. The double viral inactivated plasma product PPSB-SD is the first choice treatment in this indication because of the relatively constant, high concentrated level of the Vitamin K dependent coagulation factors II, VII, IX and X, compared to FFP.