Hsp90 Inhibitors in Parasitic Nematodes: Prospects and Challenges
Devaney, E.; Gillan, V.
Current Topics in Medicinal Chemistry 16(25): 2805-2811
2016
ISSN/ISBN: 1568-0266 PMID: 27072703 Document Number: 689585
Hsp90 inhibitors are well characterized in relation to their effects in a variety of tumors, with several inhibitors in various phases of clinical development. In recent years, the same inhibitor classes have been tested for efficacy in other systems, such as Alzheimer's disease and a variety of infectious disease models, including fungal and parasitic targets. In this article we discuss the repurposing of Hsp90 inhibitors for parasitic disease with a focus on parasitic nematode infections. We summarize the data that indicate that Hsp90 is functionally diverse in different nematode species and we discuss the challenges and prospects for developing these inhibitors as next generation chemotherapeutic tools.