Influence of Angioprotector Drugs on the Efficacy of Cytostatic Therapy (Experimental Study)
Trashkov, A.P.; Vasil'ev, A.G.; Kovalenko, A.L.; Petrov, A.Y.; Valeev, V.V.
Eksperimental'naia i Klinicheskaia Farmakologiia 79(2): 34-39
2016
ISSN/ISBN: 0869-2092 PMID: 27416681 Document Number: 688680
The influence of angioprotector and endothelium-protector drugs pentoxifylline and unifuzol as components of supportive therapy on the efficacy of combined cytostatic treatment has been experimentally studied. It is established that pentoxifylline and unifuzol do not affect the antitumor and antimetastatic activity of doxorubicin and cyclophosphan with respect to Pliss lymphosarcoma and Walker 256 carcinosarcoma, and in some cases even potentiate the effect of cytostatic therapy.