Pancreatic cancer microenvironment
Dąbkowski, K.; Bogacka, B.; Tarnowski, M.; Starzyńska, T.
Polski Merkuriusz Lekarski Organ Polskiego Towarzystwa Lekarskiego 41(246): 296-302
2016
ISSN/ISBN: 1426-9686 PMID: 28024135 Document Number: 688563
Pancreatic cancer remains one of the deadliest solid tumors in humans and an unsolved problem of today's medicine. Experimental studies reveal that the heterogeneous and complex pancreatic cancer microenvironment is responsible, not only for cancer growth, spread, development of metastases, but also for cancer recurrence and chemotherapy resistance. Chemotherapy affecting the cancer stroma is still under clinical and experimental research and remains hope for cure of pancreatic cancer. We present the cancer microenvironment characteristics and summary of experimental studies with use of agents affecting pancreatic cancer stroma.