Pancreatic amylase as a tumour marker for pancreatic cancer
Hilmy, A.M.; Kandeel, K.M.; Selim, N.M.
Archiv für Geschwulstforschung 54(6): 475-482
1984
ISSN/ISBN: 0003-911X PMID: 6084495 Document Number: 229655
Pancreatic cancer was induced in male Sprague-Dawley rats by 7,12-dimethylbenz-5.25). Purified enzyme was subjected to disc gel electrophoresis. Both normal and treated rats gave the same electrophoretics pattern (3 bands: 2 major and 1 minor). There was no isoenzyme component in pancreatic extracts of rats bearing pancreatic cancer that could be held to be peculiar for pancreatic cancer. Histological findings showed a decrease in zymogen content together with its total absence in some areas of malignant cells. The original carcinogenic events were associated with a decrease in amylase initial activity, and did not involve alteration in gene expression related to amylase biosynthesis.