The genetics of the immune response to a synthetic double-stranded RNA in a mutant CBA mouse strain
Scher, I.; Frantz, M.M.; Steinberg, A.D.
Journal of Immunology 110(5): 1396-1401
1973
ISSN/ISBN: 0022-1767 PMID: 4121424 Document Number: 68737
CBA/HN mice did not form antibody to polyinosinic-polycytidylic acid when given with complete Freund's adjuvant. All other strains investigated responded to this antigen. Genetic studies revealed that the inability to respond was associated with a gene on the X-chromosome of the CBA/HN strain. Antibody formation could be induced in this strain by giving the antigen with methylated bovine gamma -globulin. The possible mechanisms of the defect are discussed.
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