The Role of the Foxa Subfamily Factors in the Embryonic Development and Carcinogenesis of the Pancreas
Zinovyeva, M.V.; Kuzmich, A.I.; Monastyrskaya, G.S.; Sverdlov, E.D.
Molekuliarnaia Genetika Mikrobiologiia i Virusologiia 34(3): 98-103
2016
ISSN/ISBN: 0208-0613 PMID: 30383931 Document Number: 686409
The embryonic development and carcinogenesis are controlled by many transcription factors. The regulatory systems involved in embryogenesis of an organ are also involved in the tumor development in the same organ. FOX family proteins are transcription factors, which play a key role in these processes. The pioneering factors of the FOXA subfamily act at the very early stages of the embryonic development by interacting with condensed chromatin and thereby enabling the expression of the formerly silent important transcription factors. The role of these factors in tumor development is currently not fully elucidated, although recent studies indicate the important contribution of the FOXA subfamily proteins at the early stages of carcinogenesis. This review is restricted to the role of the FOXA factors in embryogenesis of the pancreas and their significance in the development of the pancreatic ductal adenocarcinoma.