Methotrexate-induced necrolysis in tumoral-stage mycosis fungoides: a challenging diagnosis
Mna, A.B.; Souissi, A.; Halouani, S.; El Euch, D.; Zahani, A.; Kchir, N.; Zaraa, I.; Mokni, M.
Dermatology Online Journal 22(1)
2016
ISSN/ISBN: 1087-2108 PMID: 26990481 Document Number: 686266
Methotrexate-induced cutaneous ulceration is a rare but potentially serious drug adverse reaction. This adverse reaction of methotrexate therapy has been initially described in psoriasis patients and is unusual in patients with cutaneous T-cell lymphoma. In 1978, Mc Donald et al reported the first three cases of cutaneous ulcerations in patients treated for a mycosis fungoides with intravenous infusions of methotrexate. Since then, few cases of methotrexate-induced skin ulcers in patients with mycosis fungoides have been published. We report an additional patient with erythrodermic mycosis fungoides who developed cutaneous ulcerations as a sole manifestation of methotrexate toxicity.